N-Arachidonylglycine
CAS No. : 179113-91-8
(Synonyms: NA-Gly)
| Size | Price | Stock |
|---|---|---|
| 138.30 mM * 1 mL in Ethanol | $308 | In-stock |
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| Cat. No. : | HY-103332 |
| M.Wt: | 361.52 |
| Formula: | C22H35NO3 |
| Purity: | >98 % |
| Solubility: | Ethanol : 50 mg/mL (ultrasonic);DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C) |
N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration[1][2].
IC50 & Target:EC50: 44.5 nM (GPR18); IC50: 5.1 μM(GLYT2)
In Vitro: N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells[1].
N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm[2].
In Vivo: N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold[3].
N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells[3].
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