Tegafur


CAS No. : 17902-23-7

(Synonyms: FT 207; NSC 148958)

17902-23-7
Price and Availability of CAS No. : 17902-23-7
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500g $379 In-stock
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Cat. No. : HY-17400
M.Wt: 200.17
Formula: C8H9FN2O3
Purity: >98 %
Solubility: DMSO : ≥ 48 mg/mL;H2O : ≥ 20 mg/mL
Introduction of 17902-23-7 :

Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil. IC50 & Target: Nucleoside antimetabolite/analog In Vitro: Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity.

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