Ac-YVAD-cmk
CAS No. : 178603-78-6
(Synonyms: Caspase-1 Inhibitor II)
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $280 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $735 | In-stock |
| 50mg | $1040 | In-stock |
| 100mg | $1450 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-16990 |
| M.Wt: | 540.99 |
| Formula: | C24H33ClN4O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].
In Vitro: Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro[2].
In Vivo: Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group[2].
Ac-YVAD-cmk (rats with ac-YVAD-cmk at a dose of 12.5 μmol/kg) significantly reduces mortality from 83 to 33% using Log Rank analysis[3].
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