VUF11207 (fumarate)
CAS No. : 1785665-61-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $170 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $600 | In-stock |
| 100mg | $1000 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110318 |
| M.Wt: | 586.65 |
| Formula: | C31H39FN2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1].
IC50 & Target:CXCR7[1].
In Vitro:VUF11207 fumarate (0.17 nM; 5 days) inhibits RANKL‑ and TNF‑α‑induced osteoclastogenesis through CXCL12 inhibition in osteoclast precursor cells[1].
VUF11207 fumarate inhibits osteoclastogenesis by suppressing phosphorylation of erk[1].
In Vivo:VUF11207 fumarate (100 µg/day; s.c.; single daily for 5 days) inhibits LPS‑induced osteoclastogenesis, bone resorption and production of RANKL and TNF‑α in mice[1].
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