AR-R17779 (hydrochloride)
CAS No. : 178419-42-6
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| 10mg | $400 | In-stock |
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| Cat. No. : | HY-135483A |
| M.Wt: | 218.68 |
| Formula: | C9H15ClN2O2 |
| Purity: | >98 % |
| Solubility: | H2O : 32 mg/mL (ultrasonic) |
AR-R17779 hydrochloride is a potent and selective full agonist of nAChR, with Kis of 92 and 16000 nM for α7 and α4β2 subtype, respectively. AR-R17779 hydrochloride can improve learning and memory in rats. AR-R17779 hydrochloride also has anxiolytic activity. AR-R17779 hydrochloride can reduce inflammation by activating antiinflammatory cholinergic (vagal) pathways[1][2][4].
IC50 & Target: IC50: 92 nM (α7-nAChR)[1]
In Vitro: AR-R17779 is 5-fold more potent and 35000-fold more selective than (-)-nicotine for the α7 nicotinic receptor[1].
AR-R17779 (200 nM; 24 h) inhibits the LPS-induced TNF production in macrophages[4].
In Vivo: AR-R17779 (1-5 mg/kg; i.p. twice a day for 7 d) ameliorates arthritis, reduces synovial inflammation, delays onset of disease and protects against joint destruction[3].
AR-R17779 (1-10 mg/kg; s.c. for 3 weeks) improves learning in two radial-arm maze tasks and reverses working memory impairment caused by fimbria-fornix sections in rats[2].
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