AUTEN-67
CAS No. : 1783800-77-0
(Synonyms: Autophagy enhancer-67)
| Size | Price | Stock |
|---|---|---|
| 1mg | $120 | In-stock |
| 5mg | $280 | In-stock |
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| Cat. No. : | HY-117924 |
| M.Wt: | 474.45 |
| Formula: | C23H14N4O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
AUTEN-67 (Autophagy enhancer-67) is an orally active autophagy enhancer and MTMR14 inhibitor. AUTEN-67 has anti-aging and neuroprotective effects. AUTEN-67 protects neurons from stress-induced cell death. AUTEN-67 also restores nesting behavior in a mice model of Alzheimer disease[1].
In Vitro:AUTEN-67 (2-100 µM, 3 h) inhibits MTMR14 by nearly 3%-70%, induces autophagic flux, and promotes the survival in HeLa cells[1].
AUTEN-67 (10-100 µM, 2 h) induces autophagy in Drosophila via inhibiting EDTP[1].
AUTEN-67 (1-50 µM) decreases levels of LC3B-II, and protects neurons from oxidative stress (increases cell viability) in murine primary neurons[1].
In Vivo:AUTEN-67 enhances autophagy in zebrafish (10, 50 µM)and mice (e 50 µmol/g body weight, i.p.)[1].
AUTEN-67 (19 mg/kg, p.o., 3 times a week, for 3 month) restores nesting behavior and decreases APP level in the Alzheimer disease mice model[1].
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