ACT-678689
CAS No. : 1783256-96-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $330 | In-stock |
| 10mg | $500 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1150 | In-stock |
| 100mg | $1550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19572 |
| M.Wt: | 565.04 |
| Formula: | C23H22ClFN6O4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
ACT-678689 (Compound Example 1.53.4) is a tryptophan hydroxylase (TPH) inhibitor with an IC50 of 8 nM[1]. IC50 & Target: IC50: 8 nM (TPH)[1] In Vitro: TPH comprises two isoforms: TPH2 is mainly expressed in neuronal cell types in the central nervous system (CNS), while TPH1 is mainly expressed in peripheral tissues, including the entrochromaffin cells (EC) in the gut, where it is responsible for synthesizing 5HT that is stored in circulating blood platelets[1].
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