Revaprazan (hydrochloride)
CAS No. : 178307-42-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $45 | In-stock |
| 25mg | $90 | In-stock |
| 50mg | $140 | In-stock |
| 100mg | $220 | In-stock |
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| Cat. No. : | HY-N7067 |
| M.Wt: | 398.90 |
| Formula: | C22H24ClFN4 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.33 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Revaprazan hydrochloride is reversible proton pump inhibitor. Revaprazan hydrochloride can inhibit gastric acid secretion and protect gastric mucosa. Revaprazan hydrochloride can inhibit IkappaB-alpha degradation as well as Akt inactivation, resulting in attenuation of H. pylori-induced COX-2 expression. Revaprazan hydrochloride can be used for the researches of infection and inflammmation, such as H. pylori-infected gastric inflammation and gastric ulcer[1][2].
IC50 & Target:Acid pump; COX-2[1]
In Vitro:Revaprazan hydrochloride (5-20 μM, 24 h) reduces H. pylori-stimulated COX-2 expression and activity in AGS cells[1].
Revaprazan hydrochloride (5-20 μM, 24 h) inhibits transcription activity of NF-κB in H. pylori-stimulated AGS cells[1].
Revaprazan hydrochloride (5-20 μM, 24 h) improves the retarded cell growth in H. pylori-stimulated AGS cells[1].
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