(-)-Aspartic acid

(-)-Aspartic acid is a pyroptosis inhibitor. (-)-Aspartic acid acts as a neurotransmitter and neuromodulator, participates in hormone synthesis and regulation, and plays a role in nervous system development and endocrine system^[5].
In Vitro:(-)-Aspartic acid (1, 10, 30 mM) inhibits HGF cell pyroptosis through the TLRs-NLRP3-caspase 1-GSDMD pathway to prevent gingival fibroblast inflammation^[1].
(-)-Aspartic acid (0.1, 1, 10 nM, 48 h) stimulates steroid production in mammalian Leydig cell lines by regulating LH receptor (LHR) exposure on the cell membrane^[2].
(-)-Aspartic acid acts as a neuropeptide co transmitter by releasing glutamate or GABA as its main neurotransmitter pathway ^[5].
(-)-Aspartic acidactivates cAMP dependent gene transcription, inhibits CREB function, reduces BDNF expression, and induces excitotoxic neuronal death^[5].
In Vivo:(-)-Aspartic acid (0.5, 1, 2, 4 μmol/g; i.p.) participates in the synthesis of testosterone in rats^[3].
(-)-Aspartic acid (2 μmol/g; i.p.) increases the secretion of gonadotropin-releasing hormone (GnRH), prolactin (PRL), luteinizing hormone (LH), and growth hormone (GH) in rats^[4].