Dihomo-γ-linolenic acid
CAS No. : 1783-84-2
(Synonyms: DGLA; all-cis-8,11,14-Eicosatrienoic acid)
| Size | Price | Stock |
|---|---|---|
| 326.28 mM * 500 μL in Ethanol | $240 | In-stock |
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| Cat. No. : | HY-A0143 |
| M.Wt: | 306.48 |
| Formula: | C20H34O2 |
| Purity: | >98 % |
| Solubility: |
Dihomo-γ-linolenic acid (DGLA) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].
IC50 & Target:Endogenous Metabolite
In Vitro:Dihomo-γ-linolenic acid attenuates pro-inflammatory gene expression in human and mouse macrophages[2].
Dihomo-γ-linolenic acid (50?μM; 24 hours) attenuates IFN-γ induced phosphorylation of STAT1 on serine 727[2].
Dihomo-γ-linolenic acid attenuates IL-1β and TNF-α induced MCP-1 and ICAM-1 expression in human macrophages[2].
Dihomo-γ-linolenic acid attenuates chemokine-driven monocytic migration and macrophage foam cell formation[2].
Dihomo-γ-linolenic acid attenuates the expression of SR-A and CD36 in human macrophages[2].
Dihomo-γ-linolenic acid modulates mitochondrial respiration[2].
Dihomo-γ-linolenic acid modulates the properties of endothelial cells and VSMC[2].
In Vivo:Dihomo-γ-linolenic acid (8?mg/mouse; i.g; twice a week; for 35 days) inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA[3].
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