Nociceptin(1-7)
CAS No. : 178249-42-8
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| Cat. No. : | HY-P1319 |
| M.Wt: | 655.70 |
| Formula: | C31H41N7O9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nociceptin (1-7) is the N-terminal bioactive fragment of nociceptin (HY-P0183). Nociceptin (1-7) is a potent ORL1?(NOP) receptor agonist with antinociceptive activity. Nociceptin (1-7) combines with nociceptin reduces hyperalgesia in vivo[1]. In Vivo: Nociceptin (1-7) (intrathecal injection; 150-1200? nmol; single dose) has no significant effect in the nociceptive thermal threshold (hyperalgesia). However, when nociceptin (1-7) is injected simultaneously with nociceptin (3.0?fmol), nociceptin-induced hyperalgesia is significantly reduced[1].
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