Hardwickiic acid
CAS No. : 1782-65-6
(Synonyms: (-)-Hardwickiic acid; (-)-Hardwikiic acid)
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| Cat. No. : | HY-N3990 |
| M.Wt: | 316.43 |
| Formula: | C20H28O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Hardwickiic acid ((-)-Hardwickiic acid) is a diterpenoid compound. Hardwickiic acid can block tetrodotoxin-sensitive voltage-dependent sodium channels and possesses multiple activities such as insecticidal, antinociceptive, and neurotransmitter release-regulating effects. Hardwickiic acid can be used in the study of neurological diseases[1][2][3].
In Vitro:Hardwickiic acid (0-100 nM; 90 s) promotes K+-evoked [3H]noradrenaline overflow in mouse hippocampal synaptosomes[1].
Hardwickiic acid (5 ppm; 24 h) causes 62% mortality in adult female Aphis craccivora aphids[2].
Hardwickiic acid (20 μM) inhibits tetrodotoxin-sensitive voltage-gated sodium channels in rat dorsal root ganglion neurons[3].
In Vivo:Hardwickiic acid (2 μg/5 μL; intrathecal injection; single dose) exhibits antinociceptive activity in both HIV-1 gp120-induced sensory neuropathy rat models and Paclitaxel (HY-B0015)-induced peripheral neuropathy rat models[3].
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