Heliquinomycin
CAS No. : 178182-49-5
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| Cat. No. : | HY-105387 |
| M.Wt: | 698.58 |
| Formula: | C33H30O17 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].
In Vitro:Heliquinomycin (18 h) shows strong inhibitory activity against Gram-positive bacteria strains with MIC values of 0.1-0.39 μM[1].
Heliquinomycin inhibits the growth of HeLa S3, LI210 leukemia, IMC,carcinoma, B16 meranoma cells, with IC50s of 0-1.6 μg/mL[1].
Heliquinomycin (30 and 100 μg/mL) inhibits topoisomerase II and I enzymes activity[2].
In Vivo:Heliquinomycin (100 mg/kg, i.p.) does not show any toxicity in mice[1].
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