Exicorilant
CAS No. : 1781244-77-6
(Synonyms: CORT 125281)
| Size | Price | Stock |
|---|---|---|
| 1mg | $140 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $990 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117880 |
| M.Wt: | 589.56 |
| Formula: | C26H23F4N7O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM[1]. Exicorilant (CORT 125281) has potential to overcome adiposity, glucose intolerance and dyslipidaemia[2].
IC50 & Target:Ki: 7 nM (GR)[1].
In Vitro: Exicorilant (CORT 125281) reverses corticosterone-mediated GR activity in murine brown adipocytes in vitro[1].
In Vivo: Exicorilant (CORT 125281) reduces body weight, fat mass and plasma lipids in HFD-fed mice[2].
Exicorilant (CORT 125281) (6, 20 or 60 mg/kg/d, for 3 weeks in mice) at different dosages reduce body weight, fat mass, plasma TG, cholesterol and FFA in a dose-dependent manner, with no effect on lean mass[2].
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