PF-04859989 (hydrochloride)
CAS No. : 177943-33-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $230 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $590 | In-stock |
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| Cat. No. : | HY-116451 |
| M.Wt: | 214.65 |
| Formula: | C9H11ClN2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic;warming;heat to 60°C);H2O : 100 mg/mL (ultrasonic) |
PF-04859989 hydrochloride is a brain-penetrant, irreversible kynurenine aminotransferase (KAT) II inhibitor with IC50s of 23 and 263 nM for hKAT II and rKAT II. PF-04859989 hydrochloride is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50s of 22, 11, and >50 μM, respectively)[1].
In Vivo: In vivo pharmacokinetic and efficacy studies in rat show that PF-04859989 is a brain-penetrant, irreversible inhibitor and is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc)[1].
Rats receiving PF-04859989 (5 mg/kg; i.p.) exhibited a significantly lower number of spontaneously active DA neurons pertrack[1].
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