Acridine (hydrochloride)

Acridine hydrochloride is a tricyclic heterocyclic aromatic compound, as well as a DNA intercalator, Fluorophore, mitochondrial function inhibitor, and Antifungal agent. Acridine hydrochloride exhibits antifungal activity against Candida albicans (MIC = 400 µg/mL, MBIC = 300 µg/mL). Acridine hydrochloride reduces mitochondrial transmembrane potential, damages mitochondrial structure, induces peripheral condensation of nuclear chromatin, and causes mild cell damage. Acridine hydrochloride induces mutagenesis in phage-infected Escherichia coli cells. Acridine hydrochloride shows no activity as a GPCR ligand, ion channel modulator, nuclear receptor ligand, or protease inhibitor. Acridine hydrochloride can be used in studies related to *Candida albicans* infection^{[1][2][3][4][5][6]}. In Vitro:Acridine hydrochloride inhibits planktonic growth of Candida albicans DAY185 with an MIC of 400 µg/mL^[3].
Acridine (24 h) hydrochloride inhibits biofilm formation in Candida albicans DAY185 with an MBIC of 300 µg/mL^[3].
Acridine hydrochloride (0.5-1.0 mM; 2 h) reduces mitochondrial transmembrane potential in primary human hepatocytes, causing ≤25% reduction at 0.5 mM and >25% reduction at 1.0 mM after 2 h of incubation, with a mitochondrial toxicity rank of 7^[5].