CCT007093
CAS No. : 176957-55-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $51 | In-stock |
| 10mg | $83 | In-stock |
| 25mg | $166 | In-stock |
| 50mg | $275 | In-stock |
| 100mg | $495 | In-stock |
| 500mg | $1375 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-15880 |
| M.Wt: | 272.39 |
| Formula: | C15H12OS2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 2.8 mg/mL;DMF : 3.33 mg/mL (ultrasonic) |
CCT007093 is an effective protein phosphatase 1D (PPM1D Wip1) inhibitor. Wip1 inhibition can activate the mTORC1 pathway and enhance hepatocyte proliferation after hepatectomy[1][2].
In Vitro: CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line[1].
CCT007093 shows specificity for MCF-7 cells, reducing viability by 40% after 2 days with no observable effect on the growth of HeLa cells[2].
CCT007093 induces P38 phosphorylation at 4 h post exposure in MCF-7 cells (sensitive to PPM1D inhibition), and does not induce P38 phosphorylation in HeLa cells (relatively resistant to PPM1D inhibition)[2].
In Vivo: CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy[1].
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