Metergoline
CAS No. : 17692-51-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $42 | In-stock |
| 50mg | $106 | In-stock |
| 100mg | $145 | In-stock |
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| Cat. No. : | HY-B1033 |
| M.Wt: | 403.52 |
| Formula: | C25H29N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 66.67 mg/mL (ultrasonic) |
Metergoline is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation[1][2][3].
In Vitro: Metergoline (3 μM) causes a 6.8±1.2 mV depolarizing shift of the steady-state activation curve of the Na+currents, and does not alter the inactivation curve[3].
In Vivo: Metergoline (5 mg/kg; i.p.) completely blocks the response to intrathecal 5-HT (2 μg)[4].
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