2-Methylquinazolin-4-ol


CAS No. : 1769-24-0

1769-24-0
Price and Availability of CAS No. : 1769-24-0
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Cat. No. : HY-W051513
M.Wt: 160.18
Formula: C9H8N2O
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic);H2O : < 0.1 mg/mL
Introduction of 1769-24-0 :

2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2]. In Vitro: 2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1].
In Vivo: 2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2].

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