KN-92
CAS No. : 176708-42-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $130 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $550 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-15517 |
| M.Wt: | 456.98 |
| Formula: | C24H25ClN2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].
In Vitro: KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2].
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