Urocortin, human
CAS No. : 176591-49-4
(Synonyms: Urocortin (human); Human urocortin; Human urocortin 1; Human urocortin I)
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| 1mg | $200 | In-stock |
| 5mg | $450 | In-stock |
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| Cat. No. : | HY-P1295 |
| M.Wt: | 4696.24 |
| Formula: | C204H337N63O64 |
| Purity: | >98 % |
| Solubility: | 1 M Acetic acid : 100 mg/mL (ultrasonic);DMSO : 2 mg/mL (ultrasonic) |
Urocortin, human, a 40-aa neuropeptide, acts as an agonist of endogenous CRF receptor, with Kis of 0.4, 0.3, and 0.5 nM for hCRF1, rCRF2α and mCRF2β, respectively. IC50 & Target:Ki: 0.4 nM (hCRF1, cell assay), 0.3 nM (rCRF2α, cell assay), and 0.5 nM (mCRF2β, cell assay)[1] In Vitro:Urocortin, human is an agonist of CRF receptor, with Kis of 0.4, 0.3, and 0.5 nM for human CRF1, rat CRF2α and mouse CRF2β receptors in cell assay, respectively[1]. In Vivo:Urocortin (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such a effect also observed in mice after 1 μg of Urocortin i.c.v. administration. Urocortin has the potential of inducing anxiogenic behavior[2].
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