ONO 1301
CAS No. : 176391-41-6
(Synonyms: ONO-AP 500-02)
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $735 | In-stock |
| 50mg | $1250 | In-stock |
| 100mg | $2100 | In-stock |
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| Cat. No. : | HY-106961 |
| M.Wt: | 428.49 |
| Formula: | C26H24N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig[1][2][3].
In Vitro: ONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM[3].
ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells[3].
In Vivo: ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis[1].
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