Fucosterol
CAS No. : 17605-67-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $142 | In-stock |
| 25mg | $285 | In-stock |
| 50mg | $427 | In-stock |
| 100mg | $634 | In-stock |
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| Cat. No. : | HY-N4103 |
| M.Wt: | 412.69 |
| Formula: | C29H48O |
| Purity: | >98 % |
| Solubility: | DMSO : < 1 mg/mL;Ethanol : 16.67 mg/mL (ultrasonic) |
Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1]. IC50 & Target: PPARα; C/EBPα[1] In Vitro: Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3].Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. In Vivo: Fucosterol (oral adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2].
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