Methyl (E)-cinnamate

Methyl (E)-cinnamate (Methyl (E)-3-phenylpropenoate) is a natural flavor compound with anti-inflammatory properties found in Alpinia katsumadai Hayata. Methyl (E)-cinnamate induces apoptosis via reduced anti-apoptotic protein expression, increased TUNEL-positive cells, and apoptotic morphological changes. Methyl (E)-cinnamate can be used for the research of abnormalities of osteoblast function in bone diseases^[1]. In Vitro:Methyl (E)-cinnamate (1-100 μM; 24-48 h) reduces cell viability and induces dose-dependent morphological shrinkage in pre-osteoblast MC3T3-E1 cells^[1].
Methyl (E)-cinnamate (10-30 μM; 24 h) upregulates cleaved PARP and cleaved caspase-3, and downregulates Survivin and Bcl-2, in pre-osteoblast MC3T3-E1 cells^[1].
Methyl (E)-cinnamate (10-30 μM; 24 h) dose-dependently inhibits ERK1/2 phosphorylation, and inhibits JNK and p38 phosphorylation at 30 μM, in pre-osteoblast MC3T3-E1 cells after 24 h of treatment^[1].
Methyl (E)-cinnamate (10-30 μM; 24 h) induces dose-dependent DNA fragmentation, measured as increased TUNEL-positive cells, in pre-osteoblast MC3T3-E1 cells^[1].
Methyl (E)-cinnamate (10-30 μM; 24 h) dose-dependently reduces cell migration rate in pre-osteoblast MC3T3-E1 cells^[1].
Methyl (E)-cinnamate (10-30 μM; 7 days) dose-dependently suppresses osteoblast differentiation^[1].
Methyl (E)-cinnamate (10-30 μM; 7 days) dose-dependently downregulates mRNA expression of osteogenic markers ALP, OCN, and OPN in pre-osteoblast MC3T3-E1 cells^[1].