Tonabersat
CAS No. : 175013-84-0
(Synonyms: SB-220453)
| Size | Price | Stock |
|---|---|---|
| 5mg | $145 | In-stock |
| 10mg | $232 | In-stock |
| 25mg | $510 | In-stock |
| 50mg | $820 | In-stock |
| 100mg | $1300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-15204 |
| M.Wt: | 391.82 |
| Formula: | C20H19ClFNO4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Tonabersat (SB-220453) is a gap-junction modulator. Tonabersat prevents inflammatory damage in the central nervous system[1][2][3]. IC50 & Target:Gap-junction[1] In Vitro: Tonabersat, a novel benzopyran derivative, inhibits cortical spreading depression (CSD) and therefore might be able to inhibit the early migraine mechanisms[1]. In Vivo: Tonabersat (10 mg/kg) significantly inhibits progression of metastatic lesions. Addition of NSC 241240 to either agent profoundly inhibits brain metastasis[2].
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