Talnetant
CAS No. : 174636-32-9
(Synonyms: SB 223412)
| Size | Price | Stock |
|---|---|---|
| 5mg | $104 | In-stock |
| 10mg | $162 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $677 | In-stock |
| 100mg | $950 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-14552 |
| M.Wt: | 382.45 |
| Formula: | C25H22N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
Talnetant (SB 223412) is a selective, competitive, brain-permeable NK3 receptor antagonist with a Ki of 1.4 nM in hNK-3-CHO cells. Talnetant is 100-fold more selective for hNK-3 relative to the hNK-2 receptor and has no affinity for hNK-1. Talnetant can be used in schizophrenia-related studies[1][2][3].
In Vitro:Talnetant (SB 223412) (0.1-1?μM) can reduce the accumulation of NKB-induced IP in U-2OS cells expressing the human NK3 receptor[3].
In Vivo:Talnetant (SB 223412) (0.5-2 mg/kg i.v., 2 min pretreatment) can inhibit the miosis induced by senktide (25 μg, i.v.) in a dose-dependent manner with an ED50 of 0.44mg/kg in conscious rabbits[1].
Talnetant (SB 223412) (i.p., 1-100 mg/kg, 1 h) can significantly attenuate senktide-induced "wet dog wagging" behavior in a dose-dependent manner, significantly increase extracellular dopamine and norepinephrine in the medial prefrontal cortex and reduce haloperidol-induced increases in dopamine levels in the vomeronasal nucleus of freely moving guinea pigs[3].
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