Amino-Tri-(carboxyethoxymethyl)-methane
CAS No. : 174362-95-9
| Size | Price | Stock |
|---|---|---|
| 100mg | $79 | In-stock |
| 250mg | $187 | In-stock |
| 500mg | $373 | In-stock |
| 1g | $595 | In-stock |
| 5g | $1355 | In-stock |
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| Cat. No. : | HY-117519 |
| M.Wt: | 337.32 |
| Formula: | C13H23NO9 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Amino-Tri-(carboxyethoxymethyl)-methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Amino-Tri-(carboxyethoxymethyl)-methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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