Dehydroabietic acid
CAS No. : 1740-19-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $70 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $310 | In-stock |
| 100mg | $400 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N6869 |
| M.Wt: | 300.44 |
| Formula: | C20H28O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice[1][2].
In Vitro:Dehydroabietic acid (0-100 μM, 30 min) decreases NO production in RAW264.7 cells[1].
Dehydroabietic acid (0-100 μM, 6 h) reduces the mRNA expression levels of inflammatory mediators including inducible nitric oxide (iNOS) and TNF-α in RAW264.7 cells[1].
Dehydroabietic acid (0-100 μM, 24 h) reduces the MyD88-induced NF-κB and AP-1 transcriptional activities in HEK293T cells[1].
Dehydroabietic acid (100 μM, 24 h) inactivates both Src and Syk kinases in Src- or Syk-overexpressing HEK293T cells[1].
Dehydroabietic acid (2.5-15 μM, 4 days) promotes 3T3-L1 adipocyte differentiation in a dose-dependent manner[2].
Dehydroabietic acid (10 μM, 0-6 days) increases mRNA expression of PPAR-γ target genes (Glut-4 and Cyp4a10) in 3T3-L1 cells[2].
In Vivo:Dehydroabietic acid (10-20 mg/kg, i.g., daily, 9 weeks) alleviates HFD-induced hepatic steatosis and inflammation in HFD mice[2].
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