Nepicastat
CAS No. : 173997-05-2
(Synonyms: SYN117; RS-25560-197)
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| Cat. No. : | HY-13289 |
| M.Wt: | 295.35 |
| Formula: | C14H15F2N3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 48 mg/mL |
Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB)[1][2][3]. IC50 & Target: IC50: 8.5 nM (bovine dopamine-beta-hydroxylase), 9 nM (human dopamine-beta-hydroxylase)[2] In Vivo: Nepicastat (3-100 mg/kg; p.o.; three consecutive times, 12 hours apart times) produces dose-dependent decreases in noradrenaline content, increases in dopamine content and increases in dopamine/noradrenaline ratio in the artery (mesenteric or renal), left ventricle[3].
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