Corynoxine B


CAS No. : 17391-18-3

17391-18-3
Price and Availability of CAS No. : 17391-18-3
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5mg $280 In-stock
10mg $460 In-stock
25mg $920 In-stock
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Cat. No. : HY-N0901A
M.Wt: 384.47
Formula: C22H28N2O4
Purity: >98 %
Solubility: DMSO : 83.33 mg/mL (ultrasonic)
Introduction of 17391-18-3 :

Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice[1][3].
In Vitro:Corynoxine B (25-100 μM, 2 h) can improve Mn induced autophagy dysregulation and neurotoxicity in SH-SY5Y human neuroblastoma cells[1].
Corynoxine B can enhance the expression of BECN1 protein and restore autophagy inhibition caused by overexpression of SNCA/α-synuclein (α-syn) in PC12 cells[2].
In Vivo:Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2[3].

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