| Size | Price | Stock |
|---|---|---|
| 5mg | $280 | In-stock |
| 10mg | $460 | In-stock |
| 25mg | $920 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-N0901A |
| M.Wt: | 384.47 |
| Formula: | C22H28N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
Corynoxine B is a natural alkaloid and autophagy inducer that can improve Mn induced cellular autophagy dysregulation and enhance clearance of alpha synuclein (alpha syn) in Parkinson's disease mice[1][3]. In Vitro:Corynoxine B (25-100 μM, 2 h) can improve Mn induced autophagy dysregulation and neurotoxicity in SH-SY5Y human neuroblastoma cells[1]. Corynoxine B can enhance the expression of BECN1 protein and restore autophagy inhibition caused by overexpression of SNCA/α-synuclein (α-syn) in PC12 cells[2]. In Vivo:Corynoxine B (5-20 mg/kg, i.p.) enhances autophagy of alpha synuclein (alpha syn) clearance in Parkinson's disease mice by targeting HMGB1/2[3].
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