PP1
CAS No. : 172889-26-8
(Synonyms: AGL 1872; EI 275)
| Size | Price | Stock |
|---|---|---|
| 5mg | $101 | In-stock |
| 10mg | $158 | In-stock |
| 50mg | $370 | In-stock |
| 100mg | $581 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13804 |
| M.Wt: | 281.36 |
| Formula: | C16H19N5 |
| Purity: | >98 % |
| Solubility: | DMSO : 28 mg/mL (ultrasonic) |
PP1 is a potent, and Src family-selective tyrosine kinase inhibitor with IC50 of 5 and 6 nM for Lck and Fyn, respectively. IC50 & Target: IC50: 5 nM (Lck), 6 nM (Fyn), 250 nM (EGFR), >50 μM (JAK2)[1] In Vitro: PP1 inhibits Lck (IC50=5 nM) and FynT (IC50=6 nM) in vitro at concentrations significantly lower than those required to inhibit ZAP-70 (IC50>100 μM), JAK2 (IC50>50 μM), the EGFR kinase, and protein kinase A. PP1 inhibits whole cell tyrosine phosphorylation and proliferation in T cells stimulated with anti-CD3 and mitogens. PP1 selectively inhibits IL-2 gene expression over GM-CSF and IL-2R gene induction in human T cells[1].
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