Pexiganan (acetate)

Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection^[1][2][3][4]. In Vitro:Pexiganan (1-256 µg/mL; 24 h) acetate exhibits comparable bactericidal activity against planktonic Staphylococcus aureus Z25.2, Pseudomonas aeruginosa Z25.1, and their dual-species cultures^[1].
Pexiganan (1-256 µg/mL; 24 h) acetate is more effective at inhibiting and eradicating Staphylococcus aureus Z25.2 biofilms than Pseudomonas aeruginosa Z25.1 or dual-species biofilms^[1].
Pexiganan (7-35 μM) acetate binds to purified bovine type I collagen with a dissociation constant of 34.01 μM^[3].
Pexiganan (5-80 μg/mL; overnight) acetate inhibits the growth of Pseudomonas aeruginosa and Staphylococcus aureus^[3].
Pexiganan (40 μg/mL; 0-60 min) acetate rapidly reduces viable counts of Pseudomonas aeruginosa (ATCC27853) and Staphylococcus aureus (ATCC29213) over 60 min, with complete elimination of P. aeruginosa by 60 min^[3].
Pexiganan (10-50 μg/mL) acetate exhibits no cytotoxicity toward rat fibroblast cells in in vitro MTT assays^[3]. In Vivo:Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces TNF-α leves in E. coli O111:B4 LPS (HY-D1056A1)-induced septic shock mice^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in E. coli-induced septic shock in male Wistar rats^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate reduces lethality, and intra-abdominal bacterial counts in in cecal ligation and puncture-induced septic shock in male Wistar rats^[4].
Pexiganan (1 mg/kg; i.p.; single dose) acetate is well-tolerated with no detectable adverse effects or physiological changes in healthy male Wistar rats^[4].