Isocucurbitacin B
CAS No. : 17278-28-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $252 | In-stock |
| 2mg | $350 | In-stock |
| 5mg | $504 | In-stock |
| 10mg | $830 | In-stock |
| 25mg | $1500 | Get quote |
| 50mg | $2500 | Get quote |
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| Cat. No. : | HY-N4189 |
| M.Wt: | 558.70 |
| Formula: | C32H46O8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Isocucurbitacin B is a natural terpenoid compound found in Pedicellus Melo. Isocucurbitacin B can inhibit the PI3K/AKT, MAPK, and STAT3 signaling pathways and downregulate CAV1 expression. Isocucurbitacin B can inhbit cancer cell proliferation, migration and invision. Isocucurbitacin B can induce apoptosis and cause G2/M phase arrest. Isocucurbitacin B can decrease intracellular cholesterol and PH levels and increase intracellular calcium levels. Isocucurbitacin B can be used for the research of cancer, such as glioma[1][2].
In Vitro: Isocucurbitacin B (0.001-25 μmol/L; 12-24 h) inhibits the proliferation of U251 and U87 cells[1][2].
Isocucurbitacin B (0-1 μmol/L; 24 h) induces U251 and GL261 cell apoptosis[1][2].
IsoCuB (0-1 μmol/L; 24 hours) blocks the cell cycle at the G2/M phase, reducing cyclin A2 and CDK1 expression in U251 cells[2].
Isocucurbitacin B (0-0.1 μmol/L; 12-36 hours) inhibits U251 and GL261 cells migration and invasion, reducing MMP2, N-cadherin, and vimentin levels[1][2].
Isocucurbitacin B (0-0.1 μmol/L; 24 h) inhibits U251 and GL261 cells invasion[1][2].
Isocucurbitacin B (0-1 μmol/L; 24 h) inhibits the activation of PI3K/AKT, MAPK, and STAT3 signaling pathways in U251 cells[1].
Isocucurbitacin B (0-1 μmol/L; 24 h) downregulates pdk1, RXRα, PPAα, and Bcl-2 mRNA expressions in U251 cells[1].
Isocucurbitacin B (0-1 μmol/L; 24 hours) decreases intracellular cholesterol and PH levels and increases intracellular calcium levels in U251 cells[2].
In Vivo: Isocucurbitacin B (2 mg/kg;i.p.; daily for 18 days from day 6) inhibits tumor growth in U251 cell-transplanted BALB/c nude mice[1].
Isocucurbitacin B (0.025-0.05 mg/L; 72 hours) reduces tumor burden in glioma cell-induced zebrafish[2].
Isocucurbitacin B (1 mg/kg; intraperitoneal; daily; 21 days from day 7) inhibits glioma growth in GL261 cell-induced glioma in C57BL/6 mice[2].
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