Fosaprepitant
CAS No. : 172673-20-0
(Synonyms: L-758298)
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| Cat. No. : | HY-14407 |
| M.Wt: | 614.41 |
| Formula: | C23H22F7N4O6P |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fosaprepitant (L-785298) is a prodrug of Aprepitant (HY-10052). Fosaprepitant is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1].
IC50 & Target: Neurokinin-1 receptor[1]
In Vivo: Fosaprepitant (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats[1].
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