Danazol (Standard)
CAS No. : 17230-88-5
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| Cat. No. : | HY-B1029R |
| M.Wt: | 337.46 |
| Formula: | C22H27NO2 |
| Purity: | >98 % |
| Solubility: |
Danazol standard inhibits the proliferation of cancer cell MDA-MB-231 and MCF-7 with IC50 of 65 µg/mL and 31 µg/mL. Danazol arrests the cell cycle at G1 phase, induces apoptosis in MDA-MB-231 through PKCα signaling pathway[1].
In Vitro:Danazol standard (0-100 μM, 18-72 h) inhibits the proliferation and the formation of capillary-like tubular structures in HUVECs[2].
Danazol standard (5-20 μM, 48 h) inhibits melanogenesis in B16 cell with an IC50 of 9.3 μM by post-transcriptionally inhibiting the expression of tyrosinase protein[3].
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