GGTI-286
CAS No. : 171744-11-9
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| Cat. No. : | HY-115489 |
| M.Wt: | 429.58 |
| Formula: | C23H31N3O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2]. IC50 & Target:IC50: 2 μM (Geranylgeranylation of Rap1A) in NIH3T3 cells[1] In Vitro:GGTI-286 (10 μM; 2 and 4 h; CHO cells) reduces nuclear localization of β-catenin and transcription dependent on β-catenin/T cell factor in mammalian cells[2].
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- Cat. No.:
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