Bis-T-23
CAS No. : 171674-76-3
(Synonyms: AG1717)
| Size | Price | Stock |
|---|---|---|
| 1mg | $350 | In-stock |
| 5mg | $828 | In-stock |
| 10mg | $1130 | In-stock |
| 25mg | $1750 | In-stock |
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| Cat. No. : | HY-123572 |
| M.Wt: | 480.43 |
| Formula: | C23H20N4O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Bis-T-23 (AG1717), tyrphostin derivative, is an HIV-I integrase inhibitor. Bis-T-23 can promote actin-dependent dynamin oligomerization. Bis-T-23 can be used for the research of HIV and chronic kidney diseases (CKD)[1][2].
In Vitro:Bis-T-23 (AG1717) (0.18 μM) can inhibit HIV-1 integrase[2].
AG1717 (2 μM) can inhibit binding of integrase to the substrate DNA[2].
In Vivo:Bis-T-23 (AG1717) (1 ng) targets actin-dependent dynamin oligomerization in podocytes to promote proper GFB function[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorate proteinuria by altering actin dynamics[1].
Bis-T-23 (i.p.; 20, 40 mg/kg) ameliorates or prevented proteinuria and diminished mesangial matrix expansion in diverse genetic and chronic models of glomerular disease in rodents[1].
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