(Rac)-Metyrapol
CAS No. : 17159-42-1
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| Cat. No. : | HY-123273 |
| M.Wt: | 228.29 |
| Formula: | C14H16N2O |
| Purity: | >98 % |
| Solubility: |
Metyrapol is a steroid 11β-hydroxylase inhibitor. Metyrapol blocks the conversion of deoxycorticosterone to corticosterone in rat adrenal homogenates. Metyrapol can be used in the study of metabolic diseases[1]. In Vitro:Racemic metyrapol (0.4 mM; 10 min preincubation, 5 min incubation), (-)-metyrapol, and (+)-metyrapol exhibit similar inhibitory activity on steroid 11β-hydroxylase in rat adrenal homogenates, with racemic metyrapol showing 40.8% inhibition at 0.4 mM[1]. In Vivo:Racemic metyrapol (0.1-0.5 mmol/kg; i.v.; single dose) and its individual enantiomers exhibit similar pharmacokinetic parameters (AUC, CL, Vss) after intravenous administration to male Wistar rats, with no significant reversible conversion to metyrapone[1].
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