Slingshot inhibitor D3
CAS No. : 1715076-35-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $610 | In-stock |
| 100mg | $900 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124366 |
| M.Wt: | 461.55 |
| Formula: | C25H19NO4S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Slingshot inhibitor D3 is a potent, selective, reversible and competitive inhibitor of Slingshot. The IC50 value for Slingshot 1 is 3 μM and the Ki value for Slingshot 2 is 3.9 μM. Slingshot inhibitor D3 has similar inhibitory activities toward both Slingshot 1 and Slingshot 2[1].
IC50 & Target: Ki: 3.9 μM (Slingshot 2)[1].
IC50: 3 μM (Slingshot 1)[1]
In Vitro: Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells;) significantly blocks NGF-induced dephosphorylation of cofilin at 15 and 30 minutes[1].
Slingshot inhibitor D3 (5 μM; 45 minutes; PC12 cells) significantly decreases the NGF-induced cell migration, consistent with its inhibitory role in cofilin dephosphorylation[1].
Slingshot inhibitor D3 (HEK293 cells) specifically blocks angiotensin II-induced cofilin dephosphorylation. Slingshot inhibitor D3 prevents cofilin dephosphroylation through inhibition of Slingshot[1].
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