Rineterkib
CAS No. : 1715025-32-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $450 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1020 | In-stock |
| 100mg | $1380 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114491 |
| M.Wt: | 578.42 |
| Formula: | C26H27BrF3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Rineterkib (compound B) is an orally available ERK1 and ERK2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly related to the treatment of KRAS-mutant NSCLC, BRAF-mutant NSCLC, KRAS-mutant pancreatic cancer, KRAS-mutant colorectal cancer (CRC) and KRAS-mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF[1][2]. IC50 & Target: ERK1/2, RAF[1]. In Vivo: Rineterkib (compound B) (50, 75 mg/kg, p.o., qd/q2d, 27 days) treatment significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice[1].
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