SLIGRL-NH2
CAS No. : 171436-38-7
(Synonyms: Protease-Activated Receptor-2 Activating Peptide)
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $190 | In-stock |
| 10mg | $300 | In-stock |
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| Cat. No. : | HY-P1308 |
| M.Wt: | 656.82 |
| Formula: | C29H56N10O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
SLIGRL-NH2 (Protease-Activated Receptor-2 Activating Peptide) is an agonist of Protease-Activated Receptor-2 (PAR-2)[1]. IC50 & Target:PAR-2[1] In Vitro:SLIGRL-NH2 is an agonist of PAR-2 and MrgprC11[1]. SLIGRL-NH2 causes an L-NAME-inhibited relaxation. Based on SLIGRL-NH2 causing a concentration-dependent relaxation with an EC50 of 10 μM in endothelium-free preparations in the presence of perivascular adipose tissue (PVAT) , 20 μM is used as a suitable ‘test’ concentration of peptide in subsequent experiments designed to evaluate the effects of potential inhibitors of ADRF release/action. In the endothelium-free aorta preparations, SLIGRL-NH2 causes a concentration-dependent relaxation in preparations only in the presence of PVAT [+PVAT, -ENDO (endothelium)][2].
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