I-BRD9
CAS No. : 1714146-59-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $352 | In-stock |
| 50mg | $627 | In-stock |
| 100mg | $1100 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18975 |
| M.Wt: | 497.55 |
| Formula: | C22H22F3N3O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 13.89 mg/mL (ultrasonic) |
I-BRD9 is a selective cellular chemical probe of bromodomain-containing protein 9 (BRD9) with pIC50 value of 7.3 μM. I-BRD9 has high selectivity for bromodomain and extra terminal domain (BET) family and highly homologous bromodomain-containing protein 7 (BRD7). I-BRD9 can be used to identify genes regulated by BRD9 in Kasumi-1 cells involved in oncology and immune response pathways[1].
In Vitro: I-BRD9 (10 μM, 6 h) has a regulation role in cancer and immunology pathways[1].
I-BRD9 (10 μM) has high BRD9 affinity and excellent broader bromodomain selectivity[1].
I-BRD9 (10 μM) has affinity for BRD9 (TR-FRET), BRD4 BD1 (TR-FRET) and BRD9 NanoBRET with pIC50 values of 7.3 μM, 5.3 μM and 6.8 μM[1].
I-BRD9 (10 μM) has high aqueous solubility (CLND) with 359 μM[1].
I-BRD9 (10 μM) displays >625 fold selectivity in binding with endogenous BRD9 against BET family member BRD3 in HUT-78 cell lysate[1].
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