Sodium zirconium cyclosilicate

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD)^[1][2]. In Vitro:Sodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K⁺ and ammonium ions. Sodium zirconium cyclosilicate has the exchange capacities for the divalent ions Ca²⁺ and Mg²⁺ are below 0.05 mEq/g, and a >25-fold selectivity for K⁺ over either Ca²⁺ or Mg^2+[1]. Dissolution Precautions: Sodium zirconium cyclosilicate can be prepared as a 1 mg/mL suspension in water as a stock solution, aliquoted, and stored at -80°C. This product is essentially an insoluble inorganic crystal that exists as a solid in the gastrointestinal tract, adsorbing potassium ions (K⁺) through an ion exchange mechanism rather than through dissolution. In Vivo:Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions^[2].