Idoxuridine (hydrate)
CAS No. : 17140-71-5
(Synonyms: 5-Iodo-2′-deoxyuridine (hydrate); 5-IUdR (hydrate); IdUrd (hydrate))
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| Cat. No. : | HY-B0307A |
| M.Wt: | 372.11 |
| Formula: | C9H13IN2O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC50 value of 4.3 μM[1]. In Vitro: Idoxuridine (2-10 μM, 72 hours) hydrate has the IC50 value of 4.3 μM of antiviral[1]. In Vivo: Idoxuridine (intraperitoneal injection, 50-200 mg/kg, 3 times, 3 hours interval) hydrate can stimulate the production of hemolysin plaque-forming cells (HPFC) to sheep red blood cells (SRBC) in C3HeB/FeJ female and male mice and A/J male mice[2].
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