(S,S)-TAPI-1
CAS No. : 171235-71-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $600 | In-stock |
| 10mg | $780 | In-stock |
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| Cat. No. : | HY-16657A |
| M.Wt: | 499.60 |
| Formula: | C26H37N5O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
(S,S)-TAPI-1 is an isomer of TAPI-1. TAPI-1 is a TACE (ADAM17) inhibitor and blocks the shedding of several cell surface proteins. TAPI-1 is also a metalloproteinase (MMP) inhibitor[1][2]. IC50 & Target:TACE (ADAM17), MMP[1][2] In Vitro:(S,S)-TAPI-1 reduces the shedding of various membrane proteins, including the exon domain (sAPPα) of amyloid precursor protein (APP). (S,S)-TAPI-1 inhibits muscarinic acetylcholine receptor M3-stimulated sAPPα release, inhibits TACE-dependent sAPPα release in TACE-overexpressing cells, and sAPPα release in non-TACE-overexpressing cells, IC50 is 3.61, 0.92 and 8.09 μM, respectively[3].
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