Zanamivir (hydrate)(5:1)
CAS No. : 171094-50-1
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| Cat. No. : | HY-13210A |
| M.Wt: | 335.91 |
| Formula: | C12H20N4O7.1/5H2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Zanamivir hydrate (5:1) is the hydrate of Zanamivir. Zanamivir is an influenza viral neuraminidase inhibitor with IC50 values of 0.95 nM and 2.7 nM for influenza A and B, respectively[1]. IC50 & Target: IC50: 0.95 nM (Influenza A); 2.7 nM (Influenza B)[1] In Vivo: Zanamivir has a poor bioavailability in oral administration, with only 4-17% of the agent. Oral delivery of Zanamivir has been a problem due to its strong hydrophilic nature that limits its transport across the intestinal epithelium. Permeation enhancers such as sodium cholate, hydroxypropyl β-cyclodextrin could be used with zanamivir to enhance the intestinal permeability[3].
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- Zanamivir (hydrate)(5:1)
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