L-Sepiapterin
CAS No. : 17094-01-8
(Synonyms: Sepiapterin)
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| 5mg | $5940 | In-stock |
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| Cat. No. : | HY-112234 |
| M.Wt: | 237.22 |
| Formula: | C9H11N5O3 |
| Purity: | >98 % |
| Solubility: |
L-Sepiapterin (Sepiapterin), is a phenylalanine hydroxylase activator, is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. L-Sepiapterin can be used for the study of hyperphenylalaninemia[1][2].
In Vitro:L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner[1].
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K[1].
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism[1].
In Vivo:Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice[2].
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