Monensin
CAS No. : 17090-79-8
(Synonyms: Monensin A)
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|---|---|---|
| 5mg | $274 | Get quote |
| 10mg | $410 | Get quote |
| 25mg | $690 | Get quote |
| 50mg | $980 | Get quote |
| 100mg | $1300 | Get quote |
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| Cat. No. : | HY-N4302 |
| M.Wt: | 670.87 |
| Formula: | C36H62O11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects[1][2][3][4].
In Vitro:Monensin (1-5 μM; 48 h) results in a marked decrease in viability in a dose-dependent manner[1].
Monensin (1-5 μM; 24 h) shows a statistically significant induction of apoptosis[1].
Monensin (0.1-1 μM; 24 h) inhibits pEGFR and its downstream targets pAKT and pERK[1].
In Vivo:Monensin (10 mg/kg; po; daily; for 6 weeks) suppresses progression of the intestinal tumors without any sign of toxicity on normal mucosa in multiple intestinal neoplasia (Min) mice[2].
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