CHPG
CAS No. : 170846-74-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $96 | In-stock |
| 25mg | $210 | In-stock |
| 50mg | $380 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-101364 |
| M.Wt: | 201.61 |
| Formula: | C8H8ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic);1M NaOH : 25 mg/mL (ultrasonic;adjust pH to 11 with NaOH) |
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
IC50 & Target: mGluR5, TSG-6/NF-κB[1], ERK, Akt[2]
In Vitro: CHPG (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].
In Vivo: CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].
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