Efaproxiral (sodium)
CAS No. : 170787-99-2
(Synonyms: RSR13 (sodium))
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| Cat. No. : | HY-13619A |
| M.Wt: | 363.38 |
| Formula: | C20H22NNaO4 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 33.33 mg/mL;DMSO : 175 mg/mL (ultrasonic) |
Efaproxiral (RSR13) sodium is a haemoglobin (Hb) synthetic allosteric modifier. Efaproxiral sodium decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy [1][2][3][4].
In Vitro:Efaproxiral sodium binds to only one pair of symmetry-related sites in the Hb central water cavity[2].
Efaproxiral sodium readily crosses the red cell membrane in the presence of serum albumin solutions[2].
Efaproxiral sodium is not inhibited from entering erythrocytes in the presence of an anion-channel blocking agent (DIDS)[2].
In Vivo:Efaproxiral (150 mg/kg, i.p.) sodium increase tumor oxygenation, and increase the tumor growth inhibition of radiotherapy over 5 days of treatment[3].
Efaproxiral sodium reduces hemoglobin-oxygen binding affinity, which facilitates oxygen release from hemoglobin into surrounding tissues and potentially increases the pO(2) of the tumors[4]
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